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COMPLEMENT C1 INHIBITOR PROTEIN
Descriptors Found:
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DeCS
Descriptor
English
:
Complement C1 Inhibitor Protein
Descriptor
Spanish
:
proteína inhibidora del complemento C1
Descriptor
Portuguese
:
Proteína Inibidora do Complemento C1
Synonyms
English
:
C1 Esterase Inhibitor
C1 INH Protein
C1 Inhibitor Protein
C1-INH Protein
C1-Inhibitor Protein
Complement C1-Inhibitor Protein
Esterase Inhibitor, C1
G1, Serpin
Plasma Protease C1 Inhibitor
SERPING1
Serpin Family G Member 1
Serpin G1
Tree Number:
D12.644.861.140.500
D12.776.124.486.274.920.250.500
D12.776.395.320
D12.776.872.140.500
Definition
English
:
An endogenous 105-kDa
plasma
glycoprotein produced primarily by the LIVER and
MONOCYTES
. It inhibits a broad spectrum of proteases, including the
COMPLEMENT C1R
and the
COMPLEMENT C1S
proteases of the CLASSICAL COMPLEMENT PATHWAY, and the
MANNOSE-BINDING PROTEIN-ASSOCIATED SERINE PROTEASES
. C1-INH-deficient individuals suffer from
HEREDITARY ANGIOEDEMA TYPES I AND II
.
Indexing Annotation
English
:
do not confuse with
COMPLEMENT C1 INACTIVATOR PROTEINS
Pharmacological Action:
Complement Inactivating Agents
Entry Combination - descr/qualif
English
:
Complement C1 Inhibitor Protein
/
deficiency
use
Hereditary Angioedema Types I and II
History Note
English
:
2006; for C1 ESTERASE INHIBITOR use COMPLEMENT C1 INACTIVATOR PROTEINS
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AN
analysis
BI
biosynthesis
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
50836
Unique Identifier:
D050718
Occurrence in VHL
:
Similar:
DeCS